Information about TOLSURA for patients

Fighting against fungal infections

How did I get this fungal infection?

Fungi, like bacteria, live in multiple places including the air and ground. Anyone can get an infection from fungi, even people who are otherwise healthy. Fungi are common in the environment, and people breathe in or come in contact with fungal spores every day without getting sick.

While people can be exposed to fungi all the time without showing affects, fungal infections can take advantage of people with weak immune systems. Some conditions may increase your risk, such as certain kinds of cancer, or a recent organ or stem cell transplant. People who might have kidney failure, HIV/AIDS, or recently stayed in the ICU can also be at risk.

Some infections, such as histoplasmosis (his-toh-plaz-moh-sis) and blastomycosis (blas-toh-mahy-koh-sis), occur in certain areas of the United States. Aspergillosis (as-per-juh-loh-sis) is an infection caused by a fungus that lives indoors and outdoors all over the country, and is another fungal infection that can cause health problems.

Your doctor has prescribed TOLSURA to you because it can help fight these types of infections.

For more information on these infections and who might be at risk, visit any of the following websites:

The CDC website on fungal infections

American Thoracic Society for information on histoplasmosis, blastomycosis, and aspergillosis

What is TOLSURA?

TOLSURA is a prescription medicine used to treat the following fungal infections in adults: blastomycosis, histoplasmosis, and aspergillosis. TOLSURA is not for use for the treatment of fungal infections of the toenails or fingernails (onychomycosis). TOLSURA is not for use in place of other medicines that contain itraconazole. It is not known if TOLSURA is safe and effective in children.

TOLSURA comes in a smaller dosage than conventional itraconazole, but delivers the same amount of drug. TOLSURA has been uniquely designed to be released in the upper small intestine, which may lead to better absorption of the medication in your body.

How should I take TOLSURA?

TOLSURA comes in a bottle that contains 60 capsules.

TOLSURA Prescription Bottle

Take TOLSURA exactly as prescribed by your doctor. Your doctor will tell you how much TOLSURA to take and when to take it.

TOLSURA must be taken with food, so you can conveniently work it into your mealtime routine.

Do not chew, crush or break TOLSURA capsules.

What do I need to know about taking TOLSURA?

It is important to take TOLSURA as your doctor has directed for as long as prescribed. Depending on the type and severity of your infection, you could be taking TOLSURA for extended periods of time. Do not take TOLSURA if you are allergic to itraconazole or any of the ingredients in TOLSURA.

Before taking TOLSURA, tell your doctor about all of your medical conditions, including if you have heart problems, lung problems, kidney problems, liver problems, or have had an allergic reaction to a medicine used to treat a fungal infection.

Before you start taking TOLSURA, tell your doctor about all the medicines you take, including prescription (especially heart medications or acid-reducing medications) and over-the-counter medicines, vitamins, and herbal supplements.

Do not take TOLSURA if you are pregnant or plan to become pregnant. It is not known if TOLSURA will harm your unborn baby. Tell your doctor if you become pregnant during treatment with TOLSURA. Tell your doctor if you are breastfeeding or plan to breastfeed. TOLSURA can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you take TOLSURA.

For more information, please see the full Prescribing Information, including the Patient Information Leaflet for TOLSURA.

Are there side effects that I should know about?

TOLSURA may cause serious side effects, including:

Congestive heart failure. TOLSURA can cause congestive heart failure or make congestive heart failure that you already have worse. Stop taking TOLSURA and call your doctor right away if you have any symptoms of congestive heart failure such as shortness of breath, swelling of your feet, ankles, or legs, sudden weight loss, increased tiredness, coughing up white or pink mucus, a fast heartbeat, or waking up at night more than you normally do.

Heart problems and other serious medical problems. Serious medical problems that affect the heart and other parts of your body can happen if you take TOLSURA with certain other medicines. Talk to your doctor about all the medications you take before taking TOLSURA.

TOLSURA can cause dizziness and vision problems. Do not drive or operate machinery until you know how TOLSURA affects you. Tell your doctor if you get dizziness or vision problems.

The most common side effects of TOLSURA include: nausea, rash, vomiting, swelling, headache, diarrhea, fatigue, fever, itching, high blood pressure, abnormal liver blood tests, stomach pain, dizziness, low potassium levels, loss of appetite, general feeling of discomfort, decreased sex drive, sleepiness, elevated levels of a type of protein (called albumin) in your urine, and erectile dysfunction.

These are not all the possible side effects of TOLSURA. For a complete list, please see the full Prescribing Information, including the Patient Information Leaflet for TOLSURA.

Both covered and denied, insured, eligible patients may pay as little as $0*

You can save on your TOLSURA prescription with the Mayne Pharma Patient Savings Card.*

*Restrictions and limitations apply. Complete Terms, Conditions, and Eligibility Criteria are included with the Mayne Pharma Patient Savings Card. Out of pocket costs may vary.

Co-pay card
Download the Savings Card

If you have questions about how to use your Mayne Pharma Patient Savings Card, please call (347)-442-7919. Be sure to use this card every time you refill your Mayne Pharma Patient prescription.